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Positive AFP3 test - anyone have info about this?

Positive AFP3 test - anyone have info about this?

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  • Lady Q 03-19-08 | 12:19 AM
  • Was told by doctor's office today that my AFP3 test was positive. This test was run @ two weeks ago (I'm 19 weeks along now). Have seen some conflicting info on internet (looked there since my doctor's office finds it tiresome to reassure expectant mothers or give them information; I don't even know if the results were too high or too low, believe one points to Down's & the other to neural tube defect).

    Am 41 years old & was told "well that puts you at greater risk" (not what I needed to hear at that moment). My husband is not much on emotional support (wouldn't even take off of work the day I had to have a D&E after I lost one baby at 12 weeks), and I have no one I can talk to about this.

    Hope none of you have dealt with this from personal experience, but has anyone heard of the percentage of false positives? They are going to run a more advanced ultrasound but because we live in the sticks they can't run one until late next week.

    One thing internet info was clear on was two of the reasons the test can be positive, and these don't apply to me: the presence of multiple babies (not in my case; know since they've run previous ultrasounds) or uncertainty about baby's actual age (there isn't much uncertainty about that). Any advice on how not to panic in the meantime?

    Thanking you all in advance,

    Lady Q

    Last edited by Lady Q; 03-19-08 at 12:22 AM..
  • ~Kelli~ ~Kelli~'s Avatar 03-19-08 | 08:01 AM
  • poor thing-- this is so hard to deal with...... from what I've learned, your baby/body can have elevated levels of proteins and not have any issues-- these elevations are just an indicator that their COULD be problems, that necessitate further tests-- level 2 US, amnio or CV test..... this bloodwork shows what your risk levels are-- and they weight that against the risk associtated with further tests to decide what is warranted-- little to no risk for an US- and they will do that to look for 'markers' of downs or other defects-- then go from there and decide if an amnio or CV is warranted--

    it's so stressful-- but I have heard of many cases with elevated blood work, and totally 'normal' results from further tests....

    I always proceeded with the blood regardless of the chance of 'false positive' results bc I needed to know.....
  • NicholeMatthew NicholeMatthew's Avatar 03-19-08 | 08:45 AM

    I had a + afp with #3, and I was off on her due date by over a week, however I 'knew' it shouldn't be. Maybe she was a late implanter?? Who knows..
    However I have a healthy girl, if not a little hyper... who is now 3.

    They have a high false positive rate... which is ok. Except worries us mommies to be.
  • cynthia cynthia's Avatar 03-19-08 | 09:12 AM
  • I had a + afp with our first. I believe my # was 191, meaning I had a 1 in 191 chance of there being a problem. Did they give you the number? The higher number the better.

    I definitely know the stress you are going through! My Dr told me that there are WAY more false positives than false negatives. I ended up having a level 2 ultrasound (which was totally normal) and then we opted for the amnio since that was the only way to know for certain what was going on. The amnio was very easy...much easier than I expected...the toughest part was waiting the 2 weeks for the results to comeback. THANKFULLY that came back normal as well. She is now 7 and totally healthy! They said I was just one of the many false positives.

    I know it is easier said than done, but try not to worry too much.

  • Dopey406 Dopey406's Avatar 03-29-08 | 06:36 PM
  • My SIL was told that they should prepare specialists for her second child because she was going to have Down's. Jillian is now 10 years old and an intelligent, smart child---and she does NOT have Down's.

    The AFP is notorious for false positives, so I wouldn't fret. I'd find out what the number is and proceed with further testing to alleviate your fears and concerns.


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